Despite the pick up factor, i have noticed that an increased weight beyond my comfort range affects my square cut and pull. This makes me stick to dead weight within in my range. If its GM - i stick to 2lb10oz and pick up index 2 (this is pretty much what you get on a GM Six6). For all other brands - 2lb9oz is my preferred weight - if the retailer has a 2lb12oz bat and it picks up like 2lb9oz ... i am happy that it picks up lighter but i cannot handle that weight and i will look for other options.
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This reflects my experience - a light pick up helps for straight bat shots, but once you need to change the plane of travel, (ie go for a horizontal bat shot) the actual weight is felt and a heavier bat makes my shot that bit slower. I am not paranoid about deadweight to the nearest half oz, but do struggle if a bat is 2 or 3 oz above my usual weight, whatever the pick up.
David