Hand loads and the centre of precussion of a cricket bat?
Norbair, assuming you are asking whether the hands/gloves affect the COP?
Current thinking on COP in relation to bat/ball sports is a slight can-of-worms, due to a paper by Hatze. However, there is a COP on the bat when impacted in a freely suspended set-up. When you add a human to the equation the location of the true fulcrum becomes tricky to pin down without the assistance of biomechanics lab with a motion capture system (something we may well be doing soon with some T20 bats to investigate kinematic differences against standard bats). Without knowing where your fulcrum is, you can't pin-point the true COP because it's about balancing the acting forces around a fulcrum.
Pro-tennis players always try to hit on the nodal sweet spot to get maximum performance and minimum discomfort from vibration, and are less bothered by translation/rotation movements from the impact as they are conditioned to control these. This should be same for cricket.
So, I suppose in conclusion, while COP is one type of sweet spot, it isn't part of the consideration in designing bats since it is heavily dependent on the person using it. The interest rightly focuses on the nodal sweet spot. That said, if you can find a bat whose nodal sweet spot is aligned to a COP, it should in theory 'feel' almost perfect. In reality you will also need the best willow and the best pressing.